Information on the thesis

The thesis of the Ph D degree with specialization 03.00.02 in biophysics. – Ivan Franko National
University of Lviv, Ministry of Education and Science of Ukraine, Lviv, 2016.
Dissertation is dedicated to the research of the free-radical reactions processes in the
tissue  of  the  rats  during  the  influence  of  biogenic  amine  –  histamine  –  and  the  sodium
hypochlorite, the solution that are used for the disintoxication of organism and purifying of   21
water supply system. It is set that histamine and sodium hypochlorite lead to the violation
of the processes of lipid peroxidation, thus in different tissues of the rats the intensity of
free-radical  reactions  is  different.  The  investigated  solutions  lead  to  the  change  of  the
balanced  work  of  antioxidant  enzymes  defence  –  superoxide  dismutase,  catalase,
glutathion  peroxidase.  It  is  educed  that  at  a  simultaneous  injection  of  histamine  and
sodium  hypochlorite  to  the  animals’  organism,  and  also  at  giving  to  drink  of  sodium
hypochlorite,  there  is  a  reduce  of  the  activity  of  the  glutathion  peroxidase  in  all
investigated tissues.
It is shown that the histamine and sodium hypochlorite cause the dystrophic changes
in the tissue cells of different organs (liver, heart tissue, kidneys, lungs).
The two-factor dispersive analysis found out that sodium hypochlorite and simultaneous action of
sodium hypochlorite and histamine considerably influence the intensity of the processes of lipid peroxidation
in the heart, blood plasma and lungs of the rats.
Key  words:  lipoperoxidation,  antioxidant  defence  system,  histamine,  sodium
hypochlorite.